Sickle cell disease

From Biocourse

1. Search the NCBI database for sickle cell anemia. What can you tell me about it?
   
2. What causes beta-zero-thalassemia? ____________________
   
3. Sickle hemoglobin is a "point mutation" meaning only one nucleic acid is exchanged resulting in sickle cell anemia. Which nucleic acid is exchanged? ____________________ in normal hemoglobin is replaced with ____________________ is sickle hemoglobin.
   
4. How does this single nucleic acid exchange cause such a deadly disease?
   
5. At which base pair position does the sickle hemoglobin mutation occur? ____________________

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